Fig. 1. Combination therapy of OVA/CHP nanogel vaccine with anti-PD-1 antibody enhances the anti-tumor efficacy. A schematic illustration of the study is shown. (A) The CHP nanogel forms complexes with OVA protein via hydrophobic interactions between the cholesteryl group of CHP and hydrophobic amino acid residues of OVA. (B) The nanogel vaccine activates antigen-specific CTLs and the anti-PD-1 antibody enhances the anti-tumor efficacy by blockade of PD-1/PD-L1 signalling.
