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. 2022 Mar 29;11:e75374. doi: 10.7554/eLife.75374

Figure 2. Fixed effect meta-analysis of inverse-variance weighted Mendelian randomization estimates for genetically predicted effects of epigenetic age acceleration on multiple cancers.

Figure 2.

Odds ratios and 95% confidence intervals are reported per 1 year increase in (A) GrimAge acceleration, (B) PhenoAge acceleration, (C) HannumAge acceleration and (D) Intrinsic HorvathAge acceleration. GrimAge, PhenoAge, HannumAge and Intrinsic HorvathAge acceleration were instrumented by 4, 11, 9, and 24 genetic variants, respectively. All meta-analysis estimates were calculated using data from UK Biobank, FinnGen and international consortia, except for colorectal cancer estimates, which exclude UK Biobank data to avoid double counting.