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. 2022 Mar 29;11:e75374. doi: 10.7554/eLife.75374

Figure 4. Scatter plot showing the effect of genetic instruments on GrimAge acceleration against their effect on colorectal cancer.

Figure 4.

FinnGen and Genetics and Epidemiology of Colorectal Cancer (GECCO) genome-wide association estimates for colorectal cancer were meta-analysed using the METAL software. UK Biobank estimates were not included in the meta-analysis to avoid double counting participants included in the GECCO consortium. Results were obtained using inverse variance weighted MR (light blue), weighted median (dark blue) and weighted mode (light green) methods.