|
Fusion of NPs and liposomal vesicles
|
| PLGA NP |
DOTAP |
pDNA |
The delivery system increased transfection efficiencies compared to free DNA. It is the first time to present NP carrying IL-12 to be efficient in gene delivery to liver cancer cells in the presence of a very high concentration of serum51
|
| CHOL-grafted PAMAM NP |
DOTAP, DOPE, CHOL |
siRNA |
The core–shell nanoparticle carrying siRNA exhibited stronger downregulation of EGFR protein expression level in MCF-7 cells in vitro and the greatest inhibition on tumour growth in vivo44
|
| PLGA NP |
DOTAP, CHOL |
BSA |
The lipid shell not only promoted in vitro cellular uptake of hybrid NPs, improved the stability and protected the integrity of the hybrid structure during long- term storage52
|
| PLGA NP |
DOTAP, CHOL |
HspX/EsxS protein |
This delivery system has a good potential to enhance immune responses against HspX EsxS antigen after subcutaneous immunization of BALB/c mice53
|
| Silver NP |
POPS |
— |
The coating presented excellent inhibition of Gram-positive and Gram-negative bacteria growth and reduced inflammatory response from bone marrow derived macrophages54
|
| Gold NPs |
PC, PS |
— |
LCHNP-based methods allow for highly sensitive detection of protein-induced membrane apposition under conditions that minimize large-scale aggregation55
|
| MgP NP |
DOTAP, CHOL |
CAT |
This LCHNP carrying CAT protected MCF-7 cells from lethal level of exogenous H2O2 and lowered the ROS levels in EA.hy 926 cells56
|
| PS NP |
DOTAP, CHOL, DOPC, and DSPE-PEG-2000 |
— |
The lipid envelopes enable the diffusion of LCHNPs into the mucus layer and promote the interaction of LCHNPs with a bacterial biofilm57
|
| |
|
Re-hydration from lipid thin-film
|
| CS-TPP NP |
Egg PL, CHOL and DPPE |
Moxifloxacin |
The mean residence time, area under the curve, apparent permeability coefficient of LCHNPs were up to 6.74-fold, 4.29-fold, and 3.29-fold higher than commercials45
|
| CS NP |
Egg PL, RHL, CHOL and DSPE-PEG-2000 |
CLR |
The CLR-loaded LCHNP exhibited excellent eradicating ability to H. pylori biofilm58
|
| PLGA NP |
DSPC, DSPE-PEG-Mal and CHOL |
ATRA |
It firstly reported that LCHNP conjugated with CD133 aptamers showed a sustained release of ATRA, presented efficiently and specifically ATRA delivery to osteosarcoma initiating cells, and achieved superior therapeutic efficacy59
|
| MSN |
PL and CHOL |
HCPT |
This HCPT-LCHNP had stronger inhibitory effects on hepatocellular carcinoma cells compared with free HCPT, providing an effective strategy for delivering poorly-soluble anticancer drugs60
|
| MSN |
Soybean PL, CHOL and PEG-2000 |
PTX, CUR |
The co-delivery LCHNP system enabled the intravenous administration of hydrophobic drugs, and sustained released trend showed strong cytotoxic effect against breast cancer cells61
|
