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. 2020 Feb 27;10(15):8594–8617. doi: 10.1039/d0ra00016g

The importance of physiological pH monitoring.

Body fluid Function Balanced pH pH imbalance Physiological Status Ref.
Saliva • Maintain healthy mouth 6.2–7.6 Acidic (<pH 5.5) • Demineralization and the breakdown of tooth enamel 55–60
• Mineral deficiency (e.g. calcium and magnesium), often due to poor digestion
• Chronic generalized periodontitis
• Protect teeth Alkaline (>pH 5.5) • Plaque formation
• Chronic generalized gingivitis
Tears • Prevent eye dryness 6.5–7.6 Acidic (<pH 5.5) • Chemical damage 61–64
Alkaline (>pH 5.5)
Urine • Excrete waste fluid from the kidneys 4.5–8.0 Acidic (<pH 5.5) • Metabolic syndrome 65–69
• Diabetic ketoacidosis (a complication of diabetes)
• Idiopathic uric acid nephrolithiasis (the process of forming a kidney stones)
• Diarrhea
• Starvation
Alkaline (>pH 5.5) • Kidney stones
• Kidney-related disorders
• Urinary tract infections (UTIs)
Sweat • Control body temperature 4.5–7.0 Acidic (<pH 5.5) • Acidosis 70–76
• Excessive sweating
Alkaline (>pH 5.5) • Electrolyte imbalance
• Cystic fibrosis
• Physical stress
• Osteoporosis
• Bone mineral loss