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. 2020 Mar 10;10(16):9587–9600. doi: 10.1039/c9ra09623j

The KEGG pathways and corresponding targets in XXT.

No. Pathway Count Target name
hsa04024 cAMP signaling pathway 7 EDNRA, AKT1, FOS, ADRB2, ADRB1, RELA, NFKBIA
hsa04668 TNF signaling pathway 12 VCAM1, AKT1, ICAM1, FOS, IL6, TNF, PTGS2, RELA, MMP9, EDN1, NFKBIA, IL1B
hsa04066 HIF-1 signaling pathway 9 AKT1, IL6, INS, RELA, BCL2, EDN1, VEGFA, NOS3, TIMP1
hsa04064 NF-kappa B signaling pathway 8 VCAM1, ICAM1, TNF, PTGS2, RELA, BCL2, NFKBIA, IL1B
hsa04151 PI3K-Akt signaling pathway 11 AKT1, IL6, INS, RELA, RXRA, BCL2, COL3A1, VEGFA, TP53, NOS3, ITGB3
hsa04071 Sphingolipid signaling pathway 6 AKT1, TNF, RELA, BCL2, TP53, NOS3
hsa04010 MAPK signaling pathway 7 AKT1, FOS, TNF, RELA, TP53, IL1B, TGFB1
hsa04370 VEGF signaling pathway 4 AKT1, PTGS2, VEGFA, NOS3
hsa04611 Platelet activation 6 AKT1, COL3A1, PTGS1, TBXA2R, NOS3, ITGB3
hsa04210 Apoptosis 6 AKT1, TNF, RELA, BCL2, TP53, NFKBIA
hsa04150 mTOR signaling pathway 3 AKT1, TNF, INS
hsa00590 Arachidonic acid metabolism 4 PTGS2, PTGS1, LTA4H, ALOX5
hsa04640 Hematopoietic cell lineage 4 IL6, TNF, IL1B, ITGB3
hsa04621 NOD-like receptor signaling pathway 5 IL6, TNF, RELA, NFKBIA, IL1B