Table 1.
Time (min) | −20 | −10 | 20 | 50 | 80 | 110 | 140 | 170 |
---|---|---|---|---|---|---|---|---|
| ||||||||
Attacks (n = 8): | 2.9 ± 0.3 | 3.4 ± 0.4 | 2.6 ± 0.4 | 3.1 ± 0.4 | 2.4 ± 0.5 | 2.7 ± 0.4 | 2.4 ± 0.3 | 2.4 ± 0.9 |
Elapsed time (s): | 61 ± 10 | 49 ± 7 | 55 ± 11 | 53 ± 5 | 49 ± 7 | 52 ± 7 | 56 ± 5 | 44 ± 10 |
Baseline cataplexy in eight narcoleptic canines perfused bilaterally with cerebrospinal fluid in the pontine reticular formation. Control levels of cataplexy were measured using the same schedule as drug perfused animals, once for each animal. The mean number of cataplectic attacks and elapsed time for two food-elicited cataplexy tests (FECT) per test period is shown. During each FECT the subject ate 10 bites of wet dog food lined up along the floor (3 m) and cataplectic attacks were scored when the animal stopped forward motion and the hind limbs were lowered towards the floor. The total time required to eat all ten bites of food and return to (or remain in) an upright position was also recorded.