Table 2.
Correlations between overall survival and mRNA expression of CISD2 analyzed by univariate and multivariate Cox regression.
| Characteristics | Total (N) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
| Age (>60 vs. ≤60) | 695 | 4.668 (3.598–6.056) | <0.001 | 1.621 (1.189–2.209) | 0.002 |
| Gender (male vs. female) | 695 | 1.262 (0.988–1.610) | 0.062 | — | |
| Histologic grade (G3 vs. G2) | 466 | 2.999 (2.007–4.480) | <0.001 | 1.929 (1.256–2.964) | 0.003 |
| Histologic grade (G4 vs. G2) | 391 | 18.615 (12.460–27.812) | <0.001 | 4.172 (2.463–-7.067) | <0.001 |
| IDH status (WT vs. Mut) | 685 | 8.551 (6.558–11.150) | <0.001 | 3.907 (2.701–5.652) | <0.001 |
| 1p/19q codeletion (noncodel vs. codel) | 688 | 4.428 (2.885–6.799) | <0.001 | 1.763 (1.063–2.923) | 0.028 |
| CISD2 (high vs. low) | 695 | 4.253 (3.231–5.596) | <0.001 | 2.053 (1.442–2.924) | <0.001 |
CISD2: CDGSH iron sulfur domain 2; CI: confidence interval; IDH: isocitrate dehydrogenase.