Table 5.
Cell type | Gene marker | GBM | LGG | ||||||
---|---|---|---|---|---|---|---|---|---|
None | Purity | None | Purity | ||||||
Cor | P value | Cor | P value | Cor | P value | Cor | P value | ||
B cells | CD19 | −0.166 | ∗ | −0.174 | ∗ | 0.006 | 0.893 | 0.018 | 0.696 |
CD79A | 0.089 | 0.275 | 0.095 | 0.267 | −0.161 | ∗∗∗ | -0.158 | ∗∗∗ | |
| |||||||||
T cells (general) | CD2 | 0.031 | 0.699 | 0.007 | 0.934 | 0.147 | ∗∗∗ | 0.158 | ∗∗∗ |
CD3D | 0.077 | 0.342 | 0.056 | 0.511 | 0.106 | ∗ | 0.115 | ∗ | |
CD3E | −0.038 | 0.637 | −0.075 | 0.382 | 0.105 | ∗ | 0.110 | ∗ | |
| |||||||||
CD8+ T cells | CD8A | 0.225 | ∗∗ | 0.202 | ∗ | 0.350 | ∗∗∗ | 0.353 | ∗∗∗ |
CD8B | 0.095 | 0.240 | 0.059 | 0.491 | −0.010 | 0.816 | −0.006 | 0.893 | |
| |||||||||
Monocyte | CD86 | 0.044 | 0.589 | 0.035 | 0.684 | −0.090 | ∗ | −0.089 | 0.050 |
| |||||||||
TAM | CCL2 | 0.046 | 0.568 | 0.033 | 0.700 | −0.046 | 0.297 | −0.035 | 0.450 |
CD68 | 0.033 | 0.684 | 0.019 | 0.824 | −0.113 | ∗ | −0.111 | ∗ | |
IL10 | 0.097 | 0.234 | 0.075 | 0.383 | −0.010 | 0.819 | 0.014 | 0.759 | |
| |||||||||
M1 | INOS (NOS2) | −0.155 | 0.056 | −0.140 | 0.101 | 0.221 | ∗∗∗ | 0.225 | ∗∗∗ |
IRF5 | −0.166 | ∗ | −0.200 | ∗ | −0.129 | ∗∗ | −0.131 | ∗∗ | |
| |||||||||
M2 | CD163 | 0.122 | 0.132 | 0.124 | 0.146 | 0.021 | 0.629 | 0.028 | 0.543 |
MS4A4A | 0.210 | ∗∗ | 0.188 | ∗ | −0.120 | ∗∗ | −0.120 | ∗∗ | |
VSIG4 | 0.135 | 0.097 | 0.122 | 0.153 | −0.170 | ∗∗∗ | −0.175 | ∗∗∗ | |
| |||||||||
Neutrophils | CCR7 | 0.165 | ∗ | 0.184 | ∗ | 0.171 | ∗∗∗ | 0.189 | ∗∗∗ |
CD66b (CEACAM8) | 0.095 | 0.242 | 0.074 | 0.388 | −0.081 | 0.066 | −0.083 | 0.068 | |
CD11b (ITGAM) | −0.142 | 0.079 | −0.140 | 0.102 | −0.127 | ∗∗ | −0.129 | ∗∗ | |
| |||||||||
NK cell | KIR2DL1 | 0.025 | 0.755 | −0.009 | 0.913 | −0.019 | 0.664 | −0.035 | 0.441 |
KIR2DL3 | −0.049 | 0.548 | −0.052 | 0.547 | 0.049 | 0.263 | 0.044 | 0.338 | |
KIR2DS4 | −0.081 | 0.319 | −0.112 | 0.190 | 0.035 | 0.429 | 0.048 | 0.290 | |
KIR3DL1 | −0.052 | 0.521 | −0.052 | 0.541 | 0.113 | ∗ | 0.107 | ∗ | |
KIR3DL2 | −0.085 | 0.298 | −0.094 | 0.271 | 0.013 | 0.774 | 0.004 | 0.922 | |
KIR3DL3 | −0.072 | 0.375 | −0.060 | 0.487 | −0.036 | 0.410 | −0.032 | 0.485 | |
| |||||||||
DC | BDCA-1 (CD1C) | 0.110 | 0.178 | 0.123 | 0.150 | −0.026 | 0.562 | −0.020 | 0.661 |
CD11c (ITGAX) | −0.161 | ∗ | −0.159 | 0.062 | −0.154 | ∗∗∗ | −0.161 | ∗∗∗ | |
HLA-DPA1 | 0.012 | 0.887 | −0.022 | 0.798 | 0.046 | 0.299 | 0.062 | 0.175 | |
HLA-DPB1 | −0.012 | 0.880 | −0.036 | 0.675 | −0.010 | 0.817 | 0.003 | 0.955 | |
HLA-DQB1 | 0.018 | 0.822 | 0.022 | 0.795 | 0.019 | 0.661 | 0.029 | 0.530 | |
HLA-DRA | 0.035 | 0.671 | 0.009 | 0.913 | 0.019 | 0.664 | 0.031 | 0.496 | |
| |||||||||
Th1 | INF-γ (IFNG) | 0.078 | 0.335 | 0.063 | 0.464 | 0.103 | ∗ | 0.111 | ∗ |
STAT1 | −0.155 | 0.056 | −0.173 | ∗ | 0.369 | ∗∗∗ | 0.367 | ∗∗∗ | |
STAT4 | 0.037 | 0.649 | 0.010 | 0.908 | 0.363 | ∗∗∗ | 0.364 | ∗∗∗ | |
T-bet (TBX21) | 0.080 | 0.328 | 0.087 | 0.308 | 0.101 | ∗ | 0.112 | ∗ | |
TNFα (TNF) | −0.048 | 0.558 | −0.059 | 0.495 | −0.149 | ∗∗∗ | -0.148 | ∗∗ | |
| |||||||||
Th2 | STAT5A | −0.331 | ∗∗∗ | −0.352 | ∗∗∗ | −0.096 | ∗ | -0.092 | ∗ |
STAT6 | −0.113 | 0.164 | −0.095 | 0.266 | 0.182 | ∗∗∗ | 0.174 | ∗∗∗ | |
GATA3 | −0.152 | 0.060 | −0.159 | 0.063 | 0.070 | 0.112 | 0.090 | ∗ | |
IL13 | −0.046 | 0.571 | −0.095 | 0.267 | −0.036 | 0.412 | −0.054 | 0.237 | |
| |||||||||
Tfh | BCL6 | −0.134 | 0.100 | −0.156 | 0.068 | −0.205 | ∗∗∗ | −0.199 | ∗∗∗ |
IL21 | 0.047 | 0.562 | 0.052 | 0.546 | 0.054 | 0.220 | 0.057 | 0.214 | |
| |||||||||
Th17 | IL17A | 0.040 | 0.627 | 0.040 | 0.640 | 0.001 | 0.976 | 0.016 | 0.720 |
| |||||||||
Treg | CCR8 | 0.004 | 0.963 | −0.023 | 0.785 | 0.166 | ∗∗∗ | 0.167 | ∗∗∗ |
FOXP3 | −0.098 | 0.226 | −0.150 | 0.078 | 0.321 | ∗∗∗ | 0.327 | ∗∗∗ | |
STAT5B | −0.214 | ∗∗ | −0.225 | ∗∗ | 0.101 | ∗ | 0.111 | ∗ | |
TGFβ (TGFB1) | −0.200 | 0.013 | −0.181 | 0.034 | −0.231 | ∗∗∗ | −0.234 | ∗∗∗ | |
| |||||||||
T cell exhaustion | CTLA4 | −0.057 | 0.486 | −0.094 | 0.273 | 0.075 | 0.088 | 0.100 | ∗ |
GZMB | −0.006 | 0.941 | −0.015 | 0.864 | 0.134 | ∗∗ | 0.143 | ∗∗ | |
PD-1 (PDCD1) | 0.114 | 0.161 | 0.094 | 0.275 | 0.045 | 0.306 | 0.032 | 0.483 | |
TIM3 (HAVCR2) | 0.049 | 0.551 | 0.043 | 0.618 | −0.094 | ∗ | −0.095 | ∗ |