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. 2022 Apr 21;2022:8133505. doi: 10.1155/2022/8133505

Table 5.

Correlations between CISD2 and gene markers of immune cells in TIMER.

Cell type Gene marker GBM LGG
None Purity None Purity
Cor P value Cor P value Cor P value Cor P value
B cells CD19 −0.166 −0.174 0.006 0.893 0.018 0.696
CD79A 0.089 0.275 0.095 0.267 −0.161 ∗∗∗ -0.158 ∗∗∗

T cells (general) CD2 0.031 0.699 0.007 0.934 0.147 ∗∗∗ 0.158 ∗∗∗
CD3D 0.077 0.342 0.056 0.511 0.106 0.115
CD3E −0.038 0.637 −0.075 0.382 0.105 0.110

CD8+ T cells CD8A 0.225 ∗∗ 0.202 0.350 ∗∗∗ 0.353 ∗∗∗
CD8B 0.095 0.240 0.059 0.491 −0.010 0.816 −0.006 0.893

Monocyte CD86 0.044 0.589 0.035 0.684 −0.090 −0.089 0.050

TAM CCL2 0.046 0.568 0.033 0.700 −0.046 0.297 −0.035 0.450
CD68 0.033 0.684 0.019 0.824 −0.113 −0.111
IL10 0.097 0.234 0.075 0.383 −0.010 0.819 0.014 0.759

M1 INOS (NOS2) −0.155 0.056 −0.140 0.101 0.221 ∗∗∗ 0.225 ∗∗∗
IRF5 −0.166 −0.200 −0.129 ∗∗ −0.131 ∗∗

M2 CD163 0.122 0.132 0.124 0.146 0.021 0.629 0.028 0.543
MS4A4A 0.210 ∗∗ 0.188 −0.120 ∗∗ −0.120 ∗∗
VSIG4 0.135 0.097 0.122 0.153 −0.170 ∗∗∗ −0.175 ∗∗∗

Neutrophils CCR7 0.165 0.184 0.171 ∗∗∗ 0.189 ∗∗∗
CD66b (CEACAM8) 0.095 0.242 0.074 0.388 −0.081 0.066 −0.083 0.068
CD11b (ITGAM) −0.142 0.079 −0.140 0.102 −0.127 ∗∗ −0.129 ∗∗

NK cell KIR2DL1 0.025 0.755 −0.009 0.913 −0.019 0.664 −0.035 0.441
KIR2DL3 −0.049 0.548 −0.052 0.547 0.049 0.263 0.044 0.338
KIR2DS4 −0.081 0.319 −0.112 0.190 0.035 0.429 0.048 0.290
KIR3DL1 −0.052 0.521 −0.052 0.541 0.113 0.107
KIR3DL2 −0.085 0.298 −0.094 0.271 0.013 0.774 0.004 0.922
KIR3DL3 −0.072 0.375 −0.060 0.487 −0.036 0.410 −0.032 0.485

DC BDCA-1 (CD1C) 0.110 0.178 0.123 0.150 −0.026 0.562 −0.020 0.661
CD11c (ITGAX) −0.161 −0.159 0.062 −0.154 ∗∗∗ −0.161 ∗∗∗
HLA-DPA1 0.012 0.887 −0.022 0.798 0.046 0.299 0.062 0.175
HLA-DPB1 −0.012 0.880 −0.036 0.675 −0.010 0.817 0.003 0.955
HLA-DQB1 0.018 0.822 0.022 0.795 0.019 0.661 0.029 0.530
HLA-DRA 0.035 0.671 0.009 0.913 0.019 0.664 0.031 0.496

Th1 INF-γ (IFNG) 0.078 0.335 0.063 0.464 0.103 0.111
STAT1 −0.155 0.056 −0.173 0.369 ∗∗∗ 0.367 ∗∗∗
STAT4 0.037 0.649 0.010 0.908 0.363 ∗∗∗ 0.364 ∗∗∗
T-bet (TBX21) 0.080 0.328 0.087 0.308 0.101 0.112
TNFα (TNF) −0.048 0.558 −0.059 0.495 −0.149 ∗∗∗ -0.148 ∗∗

Th2 STAT5A −0.331 ∗∗∗ −0.352 ∗∗∗ −0.096 -0.092
STAT6 −0.113 0.164 −0.095 0.266 0.182 ∗∗∗ 0.174 ∗∗∗
GATA3 −0.152 0.060 −0.159 0.063 0.070 0.112 0.090
IL13 −0.046 0.571 −0.095 0.267 −0.036 0.412 −0.054 0.237

Tfh BCL6 −0.134 0.100 −0.156 0.068 −0.205 ∗∗∗ −0.199 ∗∗∗
IL21 0.047 0.562 0.052 0.546 0.054 0.220 0.057 0.214

Th17 IL17A 0.040 0.627 0.040 0.640 0.001 0.976 0.016 0.720

Treg CCR8 0.004 0.963 −0.023 0.785 0.166 ∗∗∗ 0.167 ∗∗∗
FOXP3 −0.098 0.226 −0.150 0.078 0.321 ∗∗∗ 0.327 ∗∗∗
STAT5B −0.214 ∗∗ −0.225 ∗∗ 0.101 0.111
TGFβ (TGFB1) −0.200 0.013 −0.181 0.034 −0.231 ∗∗∗ −0.234 ∗∗∗

T cell exhaustion CTLA4 −0.057 0.486 −0.094 0.273 0.075 0.088 0.100
GZMB −0.006 0.941 −0.015 0.864 0.134 ∗∗ 0.143 ∗∗
PD-1 (PDCD1) 0.114 0.161 0.094 0.275 0.045 0.306 0.032 0.483
TIM3 (HAVCR2) 0.049 0.551 0.043 0.618 −0.094 −0.095