Effect of enzyme sources on the yield of 3a.

Entry	Enzymea	Yieldb (%)	Entry	Enzymea	Yieldb (%)
1	RMIM	51	6	PPL	49
2	No enzyme	3	7	TLIM	56
3	CRL	37	8	TLIMc	7
4	BCL	40	9	Papain	40
5	Novozym 435	43	10	BSA	41

^aReaction conditions: lipase (50 mg), 4-chlorobenzaldehyde (1 mmol), 1H-indole (2 mmol), water (5 mL), 45 °C, 18 h.

^bHPLC yield.

^cDenatured TLIM was obtained by treating with acetone for 24 h.