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. 2020 Mar 11;10(18):10452–10460. doi: 10.1039/d0ra00499e

Thermosensitivity and pKa of two carboxy-terminal Phe-modified dendrimersa.

Dendrimer Clear UCST Turbid LCST 20 °C 50 °C
pKa1 pKa2 pKa1 pKa2
PAMAM-Suc-Phe pH 6 pH 5 (42 °C) pH 3.5 ND 4.6 8.1 5.1 8.3
pH 3 pH 4
PAMAM-Phe-Suc pH 6 pH 5.5 (71 °C) pH 5 pH 4 (60 °C) 5.4 8.0 5.0 8.2
pH 3.5
a

ND: not detected.