Thermosensitivity and pKa of two carboxy-terminal Phe-modified dendrimersa.
Dendrimer | Clear | UCST | Turbid | LCST | 20 °C | 50 °C | ||
---|---|---|---|---|---|---|---|---|
pKa1 | pKa2 | pKa1 | pKa2 | |||||
PAMAM-Suc-Phe | pH 6 | pH 5 (42 °C) | pH 3.5 | ND | 4.6 | 8.1 | 5.1 | 8.3 |
pH 3 | pH 4 | |||||||
PAMAM-Phe-Suc | pH 6 | pH 5.5 (71 °C) | pH 5 | pH 4 (60 °C) | 5.4 | 8.0 | 5.0 | 8.2 |
pH 3.5 |
ND: not detected.