Optimizing the reaction conditions for the synthesis of cycloadduct 16a.
| Entry | Solvent | Temperature (°C) | Time (h) | Isolated yield (%) |
|---|---|---|---|---|
| 1 | Benzene | Reflux | 6 | Trace |
| 2 | MeOH | Reflux | 6 | 18 |
| 3 | CH3CN | Reflux | 6 | 32 |
| 4 | Toluene | Reflux | 6 | 64 |
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