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. 2021 Dec 17;145(3):1069–1078. doi: 10.1093/brain/awab368

Figure 6.

Figure 6

Inverse relationship between TDP-type C DNs and NL/G in temporal pole (TP) and middle frontal gyrus (MFG). (B and C) Images were obtained from Case 4, a 55-year-old male with a 10-year duration of the semantic form of primary progressive aphasia (PPA-S). (A) Image was obtained from Case 1, a 74-year-old female with a 12-year duration of PPA-S. (D) Image was obtained from Case 8, a 61-year-old female with an 11-year duration of PPA-S. In the left temporal pole, severe neuronal loss and gliosis are observed (score = 4) (A), with mild-to-moderate TDP-type C pathology (score = 2.5) (C), suggesting that inclusions may wane as neuronal dropout occurs. This is juxtaposed with B and D, which highlight the reverse relationships; in the left MFG, NL/G (B) was mild (score = 1), while the presence of TDP-type C inclusions (D) were severe (score = 4). Scale bar = 50 µm in D, and also applies to A–C.