Table 1.
Case characteristics
| Case | Age of death (years) | Age at onset (years) | Disease duration (years) | Gender | PMI (h) | Brain weight (g) | Clinical diagnosis | MND | ApoE | Comorbid pathological diagnoses |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 74 | 62 | 12 | M | 26 | 1125 | PPA | No | 3,3 | ADNC A3, B1, C3; moderate vascular disease |
| 2 | 82 | 69 | 13 | F | 31 | 1250 | PPA | No | UNK | ADNC A1, B0, C2 |
| 3 | 71 | 55 | 15 | F | 19 | 910 | PPA | No | 3,3 | None |
| 4 | 55 | 45 | 10 | M | 18 | 1430 | PPA | No | 3,3 | Pigment spheroid degeneration, basal ganglia and substantia nigra |
| 5 | 65 | 52 | 13 | F | 5 | 810a | bvFTD | No | 2,3 | None |
| 6 | 71 | 63 | 8 | F | 28 | 970 | bvFTD | Yes | 3,4 | Severe vascular disease |
| 7 | 73 | 60 | 13 | M | 6 | 1370 | PPA | No | 3,3 | ADNC A1, B0, C0; moderate vascular disease |
| 8 | 61 | 50 | 11 | F | UNK | 840 | PPA | No | 3,3 | ADNC A1, B0, C0; hippocampal sclerosis |
| 9 | 73 | 53 | 20 | F | 12 | 904 | PPA | No | 3,3 | ADNC A1, B1, C0; UMN degeneration |
| 10 | 64 | 50 | 14 | F | 12 | 900 | bvFTD | No | 3,3 | ADNC, A1, B0, C0; PLS-like pathology |
ADNC = Alzheimer’s disease neuropathological change; F = female; M = male; MND = motor neuron disease; PMI = post-mortem interval; UNK = unknown.
a
Fixed brain weight.