Table 2.
Gross atrophy in 10 FTLD-TDP-type C cases
| Case | Hippocampus | Frontal | Temporal | Parietal | Occipital | Caudate | Brainstem | Cerebellum |
|---|---|---|---|---|---|---|---|---|
| 1 | 0 | B ++ | B +++ | L ++, R+ | 0 | 0 | 0 | 0 |
| 2 | B +++ (L > R) | L ++, R + | L ++, R + | L +, R 0 | 0 | L +++, R+ | 0 | 0 |
| 3 | A +++, P ++ | B ++ (L > R) | L +++, R ++ | B ++ (L > R) | 0 | L +++, R+ | 0 | 0 |
| 4 | B + | B ++ | L +++, R ++ | B ++ | 0 | 0 | 0 | 0 |
| 5 | B + | B +++ | B +++ | B +++ | B + | +++ | MB +++ | 0 |
| 6 | B + | B +++ | B +++ | B ++ | B + | +++ | + | 0 |
| 7 | 0 | B ++ (L > R) | B +++ (L > R) | B ++ | 0 | 0 | 0 | 0 |
| 8 | L +++, R ++ | L +++, R ++ | L +++, R ++ | L ++, R+ | B + | ++ | 0 | 0 |
| 9 | B ++ | B +++ (R > L) | B +++ (R > L) | B ++ | B + | 0 | 0 | 0 |
| 10 | B + | B +++ | B +++ (L > R) | B ++ | B + | ++ | + | 0 |
With the exception of one case (Case 9), all PPA cases showed asymmetric atrophy of cortex consistent with the aphasic phenotype. Cases diagnosed with bvFTD (Cases 5, 6 and 10) showed relatively symmetric patterns of cortical atrophy at gross examination. Semiquantitative grading: 0 absent; + mild, ++ moderate; +++ severe/numerous. A = anterior; P = posterior; L = left; R = right; B = bilateral; MB = midbrain.