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. 2022 Apr 1;145(3):1038–1051. doi: 10.1093/brain/awab371

Figure 2.

Figure 2

GCase protein levels and activity in fibroblasts. Measurements were made in fibroblasts from control subjects and idiopathic Parkinson’s disease (iPD) and PD-GBA patients. (A) Western blots showing immunoreactivity for human GCase and β-actin (one replicate per cell line). (B) Semi-quantitative analysis of band intensities of the blots shown in A. (C) Measurements of GCase activity in fibroblasts from the control (n = 4), idiopathic Parkinson’s disease (n = 4) and PD-GBA (n = 5) groups (three replicates per cell line). Data are shown as individual values and mean ± SEM. Unpaired t-test was performed to compare data in control subjects versus values in the idiopathic Parkinson’s disease or PD-GBA groups. Control versus PD-GBA: P = 0.0258; F(4,3) = 3.734. *P < 0.05.