Table 1.

Cox regression analysis of prognostic factors in discovery cohort and validation cohort

Variable	Discovery cohort (Tiantan)				External validation cohort (TCGA)
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	HR (95% CL)	P-value	HR (95% CL)	P-value	HR (95% CL)	P-value	HR (95% CL)	P-value
RF scorea	1.092 (1.054–1.132)	1.07 × 10−6	1.049 (1.002–1.098)	0.0421	1.046 (1.017–1.076)	1.84 × 10−3	1.047 (1.009–1.085)	0.0136
Agea	1.058 (1.039–1.077)	2.14 × 10−9	1.032 (1.014–1.050)	4.59 × 10−4	1.056 (1.042–1.071)	1.11 × 10−15	1.035 (1.019–1.052)	1.51 × 10−5
WHO gradeb		6.66 × 10−14		0.0030		5.80 × 10−8		0.1765
III versus II	2.387 (1.203–4.734)	0.0128	1.372 (0.653–2.883)	0.4033	24.425 (3.182–187.509)	0.0021	1.00 × 105 (1.63 × 10−35−6.17 × 1044)	0.8054
IV versus II	9.714 (5.232–18.035)	5.94 × 10−13	3.195 (1.487–6.863)	0.0029	77.776 (10.535–574.192)	1.97 × 10−5	5.02 × 104 (8.16 × 10−36–3.09 × 1044)	0.8169
IDH1 statusb Mutant versus wild-type	0.163 (0.102–0.262)	6.74 × 10−14	0.567 (0.266–1.208)	0.1418	0.050 (0.020–0.124)	7.87 × 10−11	0.171 (0.045–0.651)	0.0096
1p/19q statusb Cod versus Non-Cod	0.390 (0.219–0.696)	1.43 × 10−3	0.650 (0.353–1.199)	0.1680	0.098 (0.024–0.396)	1.13 × 10−3	0.162 (0.017–1.574)	0.1166
TCGA subtypeb		4.26 × 10−13		0.4225		8.93 × 10−7		0.5494
Mes versus Cla	1.344 (0.757–2.388)	0.3128	1.132 (0.604–2.120)	0.6989	1.031 (0.689–1.542)	0.8817	1.175 (0.723–1.909)	0.5156
Neu versus Cla	0.214 (0.108–0.425)	1.01 × 10−5	0.605 (0.282–1.297)	0.1964	0.386 (0.228–0.654)	3.95 × 10−4	0.850 (0.457–1.581)	0.6084
PN versus Cla	0.173 (0.096–0.314)	7.80 × 10−9	0.634 (0.279–1.440)	0.2764	0.344 (0.210–0.564)	2.32 × 10−5	1.374 (0.768–2.456)	0.2845

Cla = classical; Cod = co-deletion;: Mes = mesenchymal; Neu = neural; PN = proneural.

^a Numerical variables.

^b Categorical variables.