TABLE 3.
Synergy of peptides with human lysozyme against E. faecalis
| Bacterium | Peptide | MIC (μg/ml)
|
FIC index | |||
|---|---|---|---|---|---|---|
| Peptide alone | Lysozyme alone | Peptide in combination | Lysozyme in combination | |||
| E. faecalis | Indolicidin | 128 | 6.3 | 8 | 3.1 | 0.56 |
| Protegrin | 16 | 6.3 | 4 | 0.39 | 0.31 | |
| LL-37 | 128 | 6.3 | 32 | 3.1 | 0.75 | |
| Bactenecin | 32 | 6.3 | 8 | 1.6 | 0.5 | |
| P. aeruginosa | Indolicidin | 128 | >50 | 128 | 25a | >1.0 |
| Protegrin | 32 | >50 | 16 | 25 | 0.75 | |
| LL-37 | 128 | >50 | 128 | 25 | >1.0 | |
| Bactenecin | 128 | >50 | 64 | 25 | 0.75 | |
a
Due to the high cost of lysozyme, a single concentration of lysozyme (25 μg/ml) was used for these experiments.