. 2022 Apr 28;12:6949. doi: 10.1038/s41598-022-10544-x

Table 3.

Statistical analysis of plasma nicotine PK parameters among adult smokers after single oral product use of three nicotine products under fasting condition.

Parameters	Comparison	IPCV (%)	Geometric mean ratio (90% CI)	p value
C_max, ng/mL	Test (NP) vs Gum	20.4	200.7 (184.5–218.5)	< 0.0001
C_max, ng/mL	Test (NP) vs Lozenge	20.4	106.5 (97.9–115.9)	0.6526
AUC_0-T, ng*h/mL	Test (NP) Gum	17.1	220.7 (205.5–236.9)	< 0.0001
AUC_0-T, ng*h/mL	Test (NP) vs Lozenge	17.1	101.4 (94.4–108.9)	1.0000

CI confidence interval, IPCV intra-participant coefficient of variation.