Fig. 8. Beneficial treatment effects of lixisenatide, semaglutide and 2c by once weekly administration in db/db mice on body weight (A and B), fasted blood glucose (C and D) and HbA1c (E and F). Effects on immunohistochemistry for insulin after three weeks treatment with saline, lixisenatide, semaglutide and 2c (G). Representative images of insulin staining in saline (H), lixisenatide (I), semaglutide (J) and 2c (K) groups. Means ± SD, n = 6. ^***P < 0.001 vs. saline, ^aP < 0.05 vs. semaglutide.