Fig. 2. A box plot to present the summary statistics of the number of SH events in the previous 12 months (primary endpoint) by treatment arm and time point.

The grey box represents the 25–75% interquartile range, the median is represented by the white line in each box and the whiskers cover the minimum to the maximum values, to the limit of 1.5× the IQR. Individual values for rates outside this limit have been excluded for clarity and are presented in Table 5. A three-level random intercept negative binomial model has been used, using a missing at random assumption (MAR) and a significance level of 2.5% (two sided). The N for each group is baseline: 49 and 50, 12 months 42 and 45 and 24 months 41 and 42 HARPdoc and BGAT respectively. Source data are available on request to SAA or IB, as described in the text.