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. 2022 Apr 28;13:2229. doi: 10.1038/s41467-022-29488-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Values below zero indicate better outcomes in HARPdoc. The data are presented as estimated mean differences and 95% confidence intervals, with open triangles representing means of 12 month data; closed triangles representing means of 24-month data and bars representing 95% confidence intervals. Analysis is by a three-level random intercept linear regression regression model. A significance level of 5% (two sided) has been used. The standardised effect sizes for other secondary endpoints were not significant and are shown, together with numerical data for the depicted parameters, and the numbers providing data at each time point in each intervention, in Tables 4 and 6. Source data are available on request to S.A.A. or I.B., as described in the text.