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. 2022 Apr 28;12:6955. doi: 10.1038/s41598-022-08091-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Proposed mechanism for the effects of miR-26a-5p on WNT5A/β-catenin signaling in tumorigenesis of upper tract urothelial carcinoma (UTUC). Our findings revealed that miR-26a-5p gene delivery may induce simultaneous suppression of WNT5A and β-catenin expression and their downstream NF-κB and MMP-9 proteins. The suppression of WNT5A/β-catenin signaling axis by miR-26a-5p restoration could reverse the processes of epithelial-to-mesenchymal transition (EMT) of UTUC cells, including E-cadherin disruption, thereby suppressing their metastasis activity.