Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 10;45(2):241–256. doi: 10.1007/s13402-021-00631-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 8 — Galanin-induced immunosuppression favors tumor growth in vivo; galanin is inversely correlated with CD8 and high levels of galanin are associated with a worse survival in patients with HNSCC. PBMCs were co-cultured with UM-SCC-29 cells under different pre-treatment conditions. Tumor growth was measured by integrated density from fluorescent images. (A) Galanin pre-treatment of PMBCs allowed a larger tumor growth compared to activated PBMCs. (B) Representative images of tumors at each condition. (C) TCGA data showing that CD8 and galanin expression are negatively associated. (D) Overall survival (OS) data from the TCGA dataset correlating high and low levels of galanin and CD8. Low galanin and high CD8 mRNA levels are associated with a better survival probability. Scale white bar represents 1 mm. *** p < 0.001