Intracellular killing activity of amoxicillin (a), clarithromycin (b), lansoprazole (c), metronidazole (d), and rifabutin (e) against the H. pylori invasive strain UdA203. Bacterial counts were determined at time zero and after 2, 4, 8, 24, and 48 h of incubation with different antibiotic concentrations (⧫, control; ■, one times the MIC; ▴, two times the MIC; ×, four times the MIC). Mean values from triplicate measurements are shown. Bars indicate the standard deviations.