Table 1:

Obesogenic chemical testing in emerging in vivo models (zebrafish, medaka, roundworm, fruit fly)

Species	Mode of action	Representative References
Danio rerio	Obesity phenotype Increased weight, adiposity, and/or lipid accumulation	Cadmium: [177], [270] DDT mixture: [271] Nonylphenol and polyethoxylates: [79] Bisphenols: [272], [27], [165] Phthalates: [176], [273], [174]| PFOS: [169]
	NAFLD phenotype Steatosis, fatty liver changes	Cadmium: [270] Benzo(a)pyrene: [274], [275] Bisphenols: [276], [277], [278], [279], [280] Phthalates: [281], [282]
	Metabolism changes Metabolomics, lipids, fatty acids, diabetic phenotype, etc.	Bisphenols: [283], [278], [165] Phthalates: [176], [284], [174] PFOS: [169]
Oryzias latipes	Obesity phenotype Increased weight, adiposity, and/or lipid accumulation	TBT: [182] TBT/PFOS: [181]
	NAFLD phenotype Steatosis, fatty liver changes
	Metabolism changes Metabolomics, lipids, fatty acids, diabetic phenotype, etc.	TBT: [182] Bisphenols: [186]
C. elegans	Obesity phenotype Increased weight, adiposity, and/or lipid accumulation	Bisphenols: [199], [285] Erythromycin: [198] PFOA: [286]
	NAFLD phenotype Steatosis, fatty liver
	Metabolism changes Metabolomics, lipids, fatty acids, diabetic phenotype, etc.	Bisphenols: [199] Erythromycin: [198] Methylmercury: [197] PFOA: [286]
Drosophila melanogaster	Obesity phenotype Increased weight, adiposity, and/or lipid accumulation	DEHP: [287]
	NAFLD phenotype Steatosis, fatty liver changes
	Metabolism changes Metabolomics, lipids, fatty acids, diabetic phenotype, etc.	PFOA: [288] PFOS: [289]

Summary table of obesogenic activity testing in the zebrafish, medaka, roundworm, and fruit fly models. Representative obesogenic chemical testing (non-exhaustive) is included to detail the diversity of contaminants examined.