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. Author manuscript; available in PMC: 2023 Apr 25.
Published in final edited form as: Dev Cell. 2022 Apr 13;57(8):1053–1067.e5. doi: 10.1016/j.devcel.2022.03.011

Figure 4: SHH is essential for progression onto the DC component and genetically defines a critical transition stage of DC genesis.

Figure 4:

(A) Whole mount of E14.5 control and SHH cKO skin. (B) UMAP of control and SHH cKO dermal cells by condition or by DA clusters (left); Sox2 on UMAP (right). (C) Diffusion maps of SHH cKO and control showing Sox2 and Lef1. (D,E) Diffusion maps (left) and pseudo-order (right) of control and K14Cre;βcatfl//fl or control and SHH cKO color-coded by DA clusters. Dashed lines delineating DA populations corresponding to Regions 1 and 2. (F) Cartoon of Regions 1 and 2 and transition zone (bracket). Scale bars, 50 µm. Related to Figure S4.