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. Author manuscript; available in PMC: 2023 Apr 29.
Published in final edited form as: Circ Res. 2022 Apr 11;130(9):1289–1305. doi: 10.1161/CIRCRESAHA.121.320704

Figure 3. Deletion of PKM2 in myeloid cells suppresses inflammation, chemotaxis, accumulation of macrophages in lesions, and promotes collagen deposition.

Figure 3.

All the mice were females. A, Quantification of pro-inflammatory cytokines in plasma (n=8, 8). B, Real-time quantitative PCR analysis of ICAM-1, VCAM-1 and E-Selectin genes from the RNA isolated from whole aortae (n=6, 6). C, Representative photomicrographs and mac3-positive cells quantification in aortic sinuses (n=10, 11). Scale bar, 500 μm. D, Chemotaxis index for transmigrated bone marrow-derived macrophages (n=7, 7). E, Representative photomicrographs and quantification of collagen deposition (Masson’s Trichrome staining) in aortic sinuses (n=10, 11). Scale bar, 100 μm. F, Fibrous cap (demarcated by the red line) was calculated as the thickness of fibrous tissue overlying the necrotic core (n=6, 6). Results were presented with mean ± SEM. Statistical analysis as indicated in the figure panels.