Inhibition of cell growth by compounds selected after the initial screening.
| ||||||
|---|---|---|---|---|---|---|
| Compound | R1 | R2 | GI50a (μM) ± SEMb | |||
| MDA-MB231 | SKBR-3 | MCF-7 | MCF-10A | |||
| 14 | 3-FC6H4 | 4-FC6H4 | 9.21 ± 0.38 | >20 | >20 | >25 |
| 16 | 3-FC6H4 | 4-BrC6H4 | 13.13 ± 0.91 | 17.16 ± 1.07 | >20 | >25 |
| 17 | 3-FC6H4 | 4-MeC6H4 | 3.96 ± 0.17 | >20 | >20 | >25 |
| 18 | 3-FC6H4 | 4-MeOC6H4 | 6.18 ± 0.43 | 16.63 ± 1.38 | >20 | >25 |
| 19 | 3-FC6H4 | 4-CF3OC6H4 | 8.56 ± 0.59 | >20 | 18.22 ± 1.28 | >25 |
| 36 | 4-ClC6H4 | 4-FC6H4 | 14.14 ± 1.52 | 19.40 ± 2.39 | >20 | >25 |
| 56 | 3-MeC6H4 | 4-MeC6H4 | 0.17 ± 0.02 | 1.26 ± 0.18 | >20 | >25 |
| 58 | 3-MeC6H4 | 4-CF3OC6H4 | 15.24 ± 1.01 | >20 | >20 | >25 |
| 61 | 4-MeC6H4 | 2-FC6H4 | 12.25 ± 1.15 | >20 | >20 | >25 |
| 62 | 4-MeC6H4 | 4-FC6H4 | 10.68 ± 0.73 | >20 | 20.15 ± 1.95 | >25 |
| 70 | 4-MeOC6H4 | 2-FC6H4 | 0.32 ± 0.04 | >20 | >20 | >25 |
| 73 | 4-MeOC6H4 | 2-ClC6H4 | 0.23 ± 0.03 | 1.10 ± 0.01 | >20 | >25 |
| 74 | 4-MeOC6H4 | 3-ClC6H4 | 1.33 ± 0.17 | 0.18 ± 0.04 | 18.30 ± 1.11 | >25 |
| 77 | 4-MeOC6H4 | 3-MeC6H4 | 0.95 ± 0.04 | 3.38 ± 0.36 | >20 | >25 |
| 78 | 4-MeOC6H4 | 2-MeOC6H4 | 13.25 ± 0.93 | 2.15 ± 0.12 | >20 | >25 |
| 81 | 4-MeOC6H4 | 3-Pyridyl | 14.01 ± 1.33 | 15.58 ± 1.06 | >20 | >25 |
| 95 | 4-CF3OC6H4 | 2-MeOC6H4 | 12.77 ± 0.76 | >20 | >20 | >25 |
| 99 | 4-CF3OC6H4 | 3-Pyridyl | 11.52 ± 1.51 | >20 | >20 | >25 |
| 100 | 4-Me2NC6H4 | Ph | 0.36 ± 0.07 | 4.19 ± 0.37 | >20 | >25 |
| 101 | 4-Me2NC6H4 | 2-FC6H4 | 0.06 ± 0.001 | 0.29 ± 0.04 | >20 | >25 |
| 102 | 4-Me2NC6H4 | 4-FC6H4 | 7.20 ± 0.94 | >20 | >20 | >25 |
| 103 | 4-Me2NC6H4 | 2-MeOC6H4 | 4.17 ± 0.33 | 3.63 ± 0.23 | >20 | >25 |
| 110 | 4-BnOC6H4 | Ph | 13.44 ± 1.18 | >20 | >20 | >25 |
| 120 | 2-Thienyl | 4-BrC6H4 | 11.73 ± 1.39 | >20 | >20 | >25 |
| 121 | 2-Thienyl | 4-MeC6H4 | 13.88 ± 1.74 | >20 | >20 | >25 |
| Methotrexatec | 0.01 ± 0.001 | ND | 5.79 ± 0.47 | ND | ||
| Nilotinibc | 0.04 ± 0.001 | 9.60 ± 0.51 | ND | ND | ||
a
Concentration (μM) required to inhibit tumor cell growth by 50%, values are mean of three independent experiments.
b
Standard error of the mean.
c
Positive controls, ND = not determined.