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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Exp Eye Res. 2022 Feb 20;218:108986. doi: 10.1016/j.exer.2022.108986

Figure 2. Retinal images of treated EAU-mice on the Clinical Symptoms of EAU.

Figure 2.

Photomicrographs of the histology of retinas from treated-mice 10 weeks after immunization with IRBP and treatment. The retinal structure of a naive mouse (Fig 2A) demonstrated its normal thickness and lengthy photoreceptors. In the retina of the EAU mice treated with PBS (vehicle) had noticeably shortened photoreceptors length and disruption of the ONL (arrow) due to inflammation (Fig 2B). Also, dense inflammatory cells (asterisk) were found in the subretinal space near the disrupted ONL area. The retinal structure in EAU mice treated with α-MSH (Fig 2C), PL8331 (Fig 2D), PL8177 (Fig 2E) and PL5000 (Fig 2F) have a similar appearance as the retinas of naive mice (Fig 2A). There was a small disruption (arrow) of ONL in the retinas of EAU mice treated with MT-II (Fig 2G). The retinas in the PG901 (Fig 2H) treated EAU mice was as damaged as the retinas in the PBS-treated EAU-mice with noticeable photoreceptor shorting and ONL disruption (arrow) with densely packed inflammatory cells (asterisk). Presented micrographs are representative images that corresponds with the mean retinal thickness of each experimental group. The scale bar is 50μm long.