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Cumulative Effects of MCr-Agonists on EAU
| Maintained Thickness‡ | IRBP-Stimulated Spleen Cells |
|||||
|---|---|---|---|---|---|---|
| Agonist | Receptors | Suppression of EAU |
Whole Retina |
ONL | IL-17 | IL-10 |
| None | n/a | − | − | − | + | − |
| α-MSH | 1,3,4,5 | + | + | + | − | + |
| PL8331 | 1,3,4,5 | + | + | + | − | + |
| PL8177 | 1 | +† | + | + | − | + |
| PL5000 | 1,3,4 | − | − | − | − | + |
| MT-II | 1,3,4 | − | − | − | + | − |
| PG-901 | 3*,4*,5 | − | − | − | + | − |
Antagonist
Not sustained
The same as normal and significantly different from EAU.
