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The pharmacological and physicochemical properties of Seltorexant. acLogP value of Seltorexant is calculated by ChemBioDraw 16.0; Log D values were quantified in n-octanol/phosphate buffer (pH 7.4) by the shake-flask method. bLetavic et al. reported the in vitro binding affinity of Seltorexant.28 cBonaventure et al. reported the pharmacokinetics of Seltorexant; single oral administration (p.o.) of Seltorexant at 30 mg/kg showed high concentration in rat brain.26
