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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Bioorg Chem. 2022 Apr 4;123:105779. doi: 10.1016/j.bioorg.2022.105779

Figure 4.

Figure 4.

(A) Representative baseline and blocking PET/CT images of [18F]Seltorexant focus on the mice brain (0–60 min, the baseline is shown as horizontal, coronal, and sagittal plane; the blockings are shown as a sagittal plane); (B) the baseline and blocking time-activity curves of [18F]Seltorexant in the mice whole brain; (C) Time-radioactivity curves for [18F]Seltorexant in the hippocampus, cerebellum, thalamus, cortex, and striatum (n = 3); (D) the normalized baseline and blocking time-activity curves [18F]Seltorexant (normalized the brain uptake curves with the highest radioactivity in the blood at each time point).