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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Bioorg Chem. 2022 Apr 4;123:105779. doi: 10.1016/j.bioorg.2022.105779

Scheme 1.

Scheme 1.

Synthesis of precursor 4. Reagents and conditions: (i) NaNO2, KI, in H2O, 90 °C, 16 h; (ii) 2H-1,2,3-triazole, N1,N2-Dimethylethane-1,2-diamine, K2CO3, CuI, THF, 90 °C, 16 h; (iii) 2-(4,6-dimethylpyrimidin-2-yl)octahydropyrrolo[3,4-c]pyrrole, DIPEA, HATU, DMF, room temperature, 16 h.