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Schematic depiction of mechanism of POPG and PI disruption of TLR signaling.
As decoy ligands, POPG and PI prevent recognition of cognate ligands (e.g., LPS) by the TLR4 co-receptors CD14 and MD2. Similarly, POPG and PI disrupt the recognition of Pam3Cys and MALP2 by TLR2/1 and TLR2/6 complexes, respectively (adapted figure from ref. [57]).
