Table 1:

Transcription factors involved in obesity and obesogen action

Adipose Tissue Transcription Factors	Abbreviation	Agonists promote:
Peroxisome proliferator-activated receptor gamma (heterodimer with RXR)	PPARγ	Increased adiposity, improved insulin sensitivity
Peroxisome proliferator-activated receptor alpha	PPARα	Decreased serum triglycerides, LDL cholesterol, increased HDL cholesterol, protection against diet-induced obesity
Peroxisome proliferator-activated receptor beta/delta	PPARβ/δ	Decreased LDL cholesterol, insulin, increased HDL cholesterol, protection against diet-induced obesity
Retinoid X receptor (heterodimer with PPARγ)	RXR	Improved insulin sensitivity, reduced hyperglycemia, hypertriglyceridemia, hyperinsulinemia, reduced weight gain and food intake
Liver Transcription Factors
Liver X receptor	LXR	Decreased visceral adiposity, increased subcutaneous adiposity, increased cholesterol, increased plasma and hepatic triglycerides
Pregnane X receptor	PXR	Enhanced hepatic lipid accumulation, fatty liver disease, increased hyperglycemia
Constitutive androstane receptor	CAR	Improved insulin sensitivity, glucose and lipid metabolism, protection against diet-induced obesity, decreased glyuose levels
Farnesoid X receptor	FXR	Increased adiposity, improved insulin resistance, increased glucose intolerance, reduced hepatic lipid accumulation
Aryl hydrocarbon receptor	AhR	Hepatic lipid accumulation, insulin resistance