Table 1.
Antiaging chemicals beneficial effects in treated in vitro POA-oocytes
| Antiaging chemical | Beneficial effects | Species | References |
|---|---|---|---|
| NAC |
↑ Spindle organization ↑ CGs and mt distribution ↓ ROS ↑ ATP |
Mouse | [72–74] |
| Melatonin |
↑ CGs distribution ↓ Cytoplasm fragmentation ↑ Cytoskeleton organization ↓ ROS ↑ GPX4, POLG2 ↑ MMP ↑ BCL2 ↓ Bax, Bad |
Mouse Pig |
[75] [76] |
| Resveratrol |
↑ Spindle morphology ↑ Chromosome alignment ↓ ROS ↑ BCL2 ↓ Caspase 3 |
Mouse Pig |
[79] |
| CoQ10 |
↑ Spindle organization ↑ Chromosome alignment ↑ CGs and mt distribution ↓ ROS |
Mouse | [80] |
| Astaxanthin |
↑ Spindle organization ↑ mt, ER, Golgi apparatus, and lysosomes functions ↓ ROS |
Pig | [81] |
| Ubiquinol-10 |
↑ Cytoskeleton organization ↑ Spindle organization ↓ ROS ↑ ATP ↑ SIRT1, PGC1A ↑ ATG5, ATG7 and LAMP2 |
Pig | [82] |
| Quercetin |
↑ Spindle organization ↑ Chromosome alignment ↑ mt distribution ↓ ROS ↑ Sirt1, Sirt2, Sirt3 ↓ Phosphorylated-Cdk1 ↑ MAPK1/3, cyclin B ↑ BCL2 ↓ Caspase 3 |
Mouse | [83] |
| Icariin |
↑ Spindle organization ↑ Chromosome alignment ↑ mt distribution ↓ ROS |
Pig | [46] |
| Artemisia asiatica |
↑ Spindle organization ↑ Chromosome alignment ↑ mt distribution ↓ ROS ↑ BCL2 |
Mouse | [84] |
| Bezafibrate |
↓ ROS ↑ GSH ↓ Caspase 3 |
Pig | [85] |
| Imperatorin |
↓ ROS ↑ MMP ↑ GSH ↑ SOD, CAT ↑ BCL2 ↑ ATG5, ATG7, and LAMP2 |
Pig | [86] |
| Caffein |
↑ SIRTs ↓ Ca2+ |
Mouse | [63, 87] |
| Putrescine |
↓ ROS ↑ SOD2, SIRT1, FOXO3 ↑ MMP ↓ Phosphorylated-Cdk1 ↑ MAPK1/3, cyclin B ↑ BCL2 ↓ Caspase 3 and 9 |
Pig | [60] |
| RO-3306 |
↓ Phosphorylated-Cdk1 ↑ Cyclin B1 |
Rat | [88] |
Abbreviations: ATG, autophagy protein; Bad, BCL2-associated agonist of cell death; Bax, BCL2-associated X protein; BCL2, B-cell lymphoma 2; CAT, catalase; Cdk1, cyclin-dependent kinase 1; CGs, cortical granules; CoQ10, coenzyme Q10; FOXO3, forkhead box protein O3; GPX4. phospholipid hydroperoxide glutathione peroxidase; GSH, glutathione; LAMP2, lysosome-associated membrane glycoprotein 2; MAPK, mitogen-activated protein kinase; MMP, mitochondrial membrane potential; mt, mitochondria; NAC, N-acetyl-L-cysteine; PGC1A, peroxisome proliferator-activated receptor gamma coactivator 1-α; POLG2, mitochondrial DNA polymerase subunit gamma-2; SOD, superoxide dismutase