Table 2.
Pregnancy, live birth and miscarriage rate among the 3 groups
| Group 1 Biopsied Day-5—Vitrified |
Group 2 Vitrified day 5-Biopsied- Re-Vitrified |
Group 3 Vitrified Day 3- Biopsied day 5- Re-Vitrified |
(GEE) p, OR, CI 95% |
|
|---|---|---|---|---|
| Pregnancy rate | 65.2% (294/451) * | 67.8% (99/146) | 66.0% (64/97) | |
| Ref. group | 1.09 (0.62–1.91), p = 0.77 | 0.97 (0.61–1.53), p = 0.88 | Unadjusted | |
| 1.07 (0.68–1.64), p = 0.78 | 1.22 (0.74–1.99), p = 0.44 | Adjusted | ||
| Clinical pregnancy rate | 62.3% (281/451) | 62.3% (91/146) | 62.9% (61/97) | |
| Ref. Group | 1.00, (0.66–1.50), p = 0.99 | 1.02, (0.65–1.61), p = 0.91 | Unadjusted | |
| 0.89, (0.58–1.37), p = 0.60 | 1.21, (0.75–1.96), p = 0.44 | Adjusted | ||
| Live birth rate | 56.8% (256/451) | 54.8% (80/146) | 56.7% (55/97) | |
| Ref. Group | 0.93 (0.55–1.56), p = 0.77 | 1.00 (0.65–1.55), p = 0.99 | Unadjusted | |
| 0.85 (0.56–1.28), p = 0.43 | 1.15 (0.73–1.80), p = 0.54 | Adjusted | ||
| Clinical miscarriage | 7.8% (22/281) | 11.0% (10/91) | 9.8% (6/61) | |
| Ref. Group | 1.45, (0.67–3.17), p = 0.35 | 1.28, (0.50–3.30), p = 0.60 | Unadjusted | |
| 1.35, (0.59–3.06), p = 0.47 | 1.24, (0.50–3.10), p = 0.64 | Adjusted |
The outcomes are presented as unadjusted and adjusted values for age at the oocyte collection, BMI, endometrial thickness, semen source, endometrial preparation method, biopsy day, embryo quality category and any of their 2-way interactions that were statistically significant.
*The percentages for reproductive outcomes are used to demonstrate the magnitude of the outcomes and are not directly comparable. Since patients had more than one treatment cycle included in the study and as the treatment cycles of the same patient are not independent of each other, the outcomes can be compared with the Odd Ratios from GEE.