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. 2022 Apr 28;13:2336. doi: 10.1038/s41467-022-29938-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a In vivo time-dependent ultrasonic imaging of 4T1 tumor-bearing mice after intratumoral implantation with MgG rods. b Quantitative analysis of signal intensities based on ultrasonic imaging data. c Time-dependent pH value changes of tumors in mice post intratumoral implantation with Mg rods or MgG rods. d Ex vivo fluorescence images of tumors after implantation of MgG for different periods of time. e Tumor fluorescence (FL) signal ratios (480/440) based on ex vivo fluorescence imaging data in (C). f–h The quantification results of MDSCs (CD45⁺CD11b⁺Gr-1⁺, f), T cells (CD3⁺, g), CD8⁺ T cells (CD3⁺CD8⁺, h) by flow cytometry on day 6 post-MgG implantation. i The flow cytometric analysis results of CD8⁺ T cells (CD3⁺CD8⁺) within the tumors after different treatments. j The growth curves of tumors after various treatments. k Survival rates of tumor-bearing mice after various treatments. l Microscopy images of H&E and TUNEL stained tumor slices collected from mice post different treatment groups. m In vivo bioluminescence images of mice bearing subcutaneous 4T1 tumors expressing firefly luciferase (Luc-4T1) to display the therapeutic efficacy of mice after various treatments. n = 3 biologically independent animals in (b, c). n = 4 biologically independent animals in (e). n = 5 biologically independent animals in (f–h). n = 10 biologically independent animals in (j). A representative image of three biologically independent animals from each group is shown in (a, l). Data are presented as mean values ± SD. P values calculated by the two-tailed student’s t test are indicated in the Figures.