Figure 2.

Baclofen treatment corrected social interaction and novelty recognition deficits in F1 mice. S1 = stranger 1 mouse; S2 = stranger 2 mouse; E = empty. (A) Representative traces and heatmaps of mice in the sociability phase (scene 1). (B) Representative traces and heatmaps of mice in the preference for the social novelty phase (scene 2). (C) The time that tested mice entered the region of empty cage for sniffing in scene 1. (D) The time that tested mice entered the region containing stranger 1 for sniffing in scene 1. (E) The time that tested mice entered the region containing stranger 1 for sniffing in scene 2. (F) The time that tested mice entered the region containing stranger 2 for sniffing in scene 2. (G) The SPI of tested mice in scene 2. (H,I) Representative traces and heatmaps of tested mice in the novel object recognition task. (H) Traces of mice exploring the regions containing the two similar objects (white plastic bottles) in phase 1 (scene 1). (I) Traces of mice exploring the region containing the novel object (black glass bottle) in phase 2 (scene 2). This test was used to assess novelty recognition ability. (J) The total time spent sniffing the two objects by each group of mice in scene 1. (K) The time spent sniffing the novel object by each group of mice in scene 2. (L) The discrimination index (DI) for each group of mice in scene 2. (C–G,J–L) One-way ANOVA followed by the Bonferroni post-hoc test was used: *p < 0.05, **p < 0.01, ***p < 0.001. All data for all figures are plotted as the mean ± SEM. Each group had 14 mice (n = 14)