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. 2020 Mar 31;10(22):12788–12799. doi: 10.1039/d0ra00386g

Physical state and melting point of cinnarizine free base, HCl salt and series one sulfates.

graphic file with name d0ra00386g-u1.jpg
# Name Physical state T m/Tg (°C)
1 Free base Crystalline 122–123
1a Hydrochloride Crystalline 207
1b 1-Hexyl sulfate (C6) Amorphous 35–36
1c 1-Octyl sulfate (C8) Viscous oil <25
1d 1-Decyl sulfate (C10) Viscous oil <25
1e 1-Dodecyl sulfate (C12) Viscous oil <25
1f 1-Tetradecyl sulfate (C14) Viscous oil <25
1g 1-Hexadecyl sulfate (C16) Viscous oil <25
1h 1-Octadecyl sulfate (C18) Viscous oil <25a
a

Cinnarizine 1-octadecyl sulfate showed signs of crystallization after long term storage.