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. 2022 Apr 28;13:2299. doi: 10.1038/s41467-022-29998-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The ulcerative colitis (UC)-associated signalling network contains proteins affected by—associated single nucleotide polymorphisms (SNPs), their interactor partners as well as the transcription factors(TF) and micro-RNAs(miRNA) whose binding or target sites are affected by a SNP. Circles represent proteins and squares represent regulators (red = TFs, blue = miRNAs). Nodes are coloured according to network modules. The modules are named by their representative function. At the top right side of the network are TFs involved in potential regulatory feedback loops in UC pathogenesis. b Visualisation of the two regulatory modules. The module on the left represents the transcription factor binding sites based effects on the downstream network, which affects almost the entire signalling network. The module on the right represents the microRNA-target site based effects that mainly happen by regulating PRKCB.