Table 1.
Affected SNPs in the UC-associated signalling network, their target genes and interactionsa.
| SNP | Target gene name | Regulatory annotation of the SNP |
|---|---|---|
| rs11041476 | LSP1 | TFBS in an enhancer, miRNA-TS in the first intron |
| TNNI2 | TFBS in an enhancer | |
| rs11168249 | RAPGEF3 | TFBS in an enhancer |
| HDAC7 | TFBS in an enhancer, miRNA-TS in the first intron | |
| rs11676348 | ARPC2 | TFBS in an enhancer |
| CXCR1 | ||
| CXCR2 | ||
| SLC11A1 | ||
| CTDSP1 | ||
| rs12254167 | CCNY | TFBS in an enhancer |
| rs1598859 | NFKB1 | TFBS in an enhancer |
| CISD2 | ||
| rs17085007 | RPL21 | TFBS in an enhancer |
| GTF3A | ||
| rs1801274 | FCGR2A | miRNA-TS in an exon |
| rs3774937 | NFKB1 | miRNA-TS in an intron |
| rs477515 | HLA-DQA2 | TFBS in an enhancer |
| HLA-DQB1 | ||
| HLA-DQB2 | ||
| C4A | ||
| HSPA1B | ||
| HLA-DPA1 | ||
| AGER | ||
| NOTCH4 | ||
| rs543104 | CCDC82 | TFBS in an enhancer |
| rs559928 | RPS6KA4 | TFBS in an enhancer |
| rs6087990 | DNMT3B | TFBS in a promoter |
| rs7404095 | PRKCB | miRNA-TS in a intron |
| rs907611 | LSP1 | TFBS in a promoter |
| rs913678 | SNAI1 | TFBS in an enhancer |
| CEBPB | ||
| PTPN1 | ||
| rs943072 | VEGFA | TFBS in an enhancer |
| XPO5 | ||
| POLH |
aDetails of each interaction are provided in Supplementary Table 1. Cluster-driving SNPs affecting the regulation of a high number of proteins directly or through their first neighbours are shown in bold.