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. 2022 Apr 15;10:850912. doi: 10.3389/fped.2022.850912

Table 2.

Major aetiological causes of chronic cough in children* and examples.

1 Post-infectious: typically shows spontaneous resolution over time
2 Airway infections (protracted/recurrent/persistent): Protracted bacterial bronchitis, chronic suppurative lung disease, bronchiectasis, cystic fibrosis, immune deficiency/ciliary dyskinesia, alpha-1 antitrypsin deficiency, other chronic infections e.g., tuberculosis and atypical mycobacteria
3 Airway anomaly: Primary or secondary tracheobronchomalacia, congenital airway and pulmonary malformation
4 Airway inflammation: Asthma, eosinophilic bronchitis, environmental pollutants
5 Airway aspiration: Primary airway aspiration, secondary aspiration owing to gastroesophageal reflux, foreign body aspiration
6 Upper airway associations: Rhinitis, sinusitis
7 Tic and somatic syndrome
8 Extra-pulmonary: Drug-induced, cardiac, vagal nerve branches stimulation (e.g., Arnold's ear reflex)
9 Other specific diseases associated with chronic cough: Interstitial lung disease or tumors

*Some overlap, for example, chronic cough related to primary ciliary dyskinesia can be both infection and inflammation.