Figure 2.

CD38- and CD27-based TAM-TB signals are independent of sputum bacterial load proxies at time of diagnosis. (A–D) Linear regression analysis comparing the strength of the association between CD27 or CD38 biomarker expression by Mtb-specific CD4 T cells (CD27- or CD38-based TAM-TB) and sputum molecular bacterial load assay (MBLA) or Xpert MTB/RIF results from, respectively, blood and sputum specimen of TB patients at time of diagnosis. Regression analysis was performed including (red lines and statistical results) or excluding (black lines and statistical results) potential outliers (red squares) identified using the ROUT method.