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. 2022 Apr 15;9:861586. doi: 10.3389/fmed.2022.861586

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Copyright © 2022 Souza, Mendes, Sperandio da Silva, Sammarco-Rosa, Moraes, Jardim, Sarno, Pinheiro and Mietto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression pattern of genes involved in Schwann cell biology. Gene expression profile analysis of upregulated and downregulated mRNA transcripts from signaling pathways related to peripheral neuropathy, Schwann cell plasticity and regeneration support. Analysis were performed in human nerve biopsies from leprosy (A, black bars) and non-leprosy individuals (A, horizontal line) and in human Schwann cells (B-D) infected with dead M. leprae (white bars) and viable M. leprae (black bars); results are presented as mean ± SD from three to eight normalized independent biological replicates; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.