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. 2022 Apr 27;9(1):e000871. doi: 10.1136/bmjgast-2022-000871

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Relative abundance of Bifidobacterium in SARS-CoV-2 positive patients (n=50) versus SARS-CoV-2 negative exposed controls (n=20). Data are plotted as (A) mean with error bars for 95% CI and (B) individual points of relative abundance for varying SARS-CoV-2 infection severity. Analysed via Kruskal-Wallis test, there were significant reductions in Bifidobacterium relative abundance for severely (p<0.0001) and moderately (p=0.0002) symptomatic patients. Subjects 1–28 = severely symptomatic; subjects 29–40 = moderately symptomatic; subjects 41–46 = mildly symptomatic subjects; subjects 47–50 = asymptomatic; subjects 51–70 = exposed control. Figure A, B depicts same data.