Table 3.
Relative abundance of Bacteroides increases and those of Bifidobacterium, Faecalibacterium and Roseburium decrease with increasing severity of disease
| Genus (±species) |
Relative abundance (mean±SEM) | |||||
| Main effect | Severe | Moderate | Mild | Asymptomatic | Exposed control | |
| A. Relative abundance of genera/species for various severities of SARS-CoV-2 positivity, as well as exposed controls (SARS-CoV-2 negative). Overall p value of Kruskal-Wallis test is indicated in ‘Main Effect’ column. | ||||||
| Alistipes | 0.8119 | 0.0793±0.0166 | 0.0520±0.0084 | 0.0664±0.0196 | 0.0901±0.0272 | 0.0639±0.0095 |
| Bacteroides | 0.0075 | 0.2187±0.0272 | 0.2849±0.0305 | 0.0912±0.0226 | 0.2058±0.0606 | 0.1235±0.0178 |
| Bifidobacterium | <0.0001 | 0.0018±0.0006 | 0.0037±0.0015 | 0.0507±0.0244 | 0.0840±0.0308 | 0.0755±0.0219 |
| Blautia | 0.2098 | 0.0495±0.0095 | 0.0426±0.0132 | 0.1037±0.0510 | 0.0260±0.0067 | 0.0261±0.0040 |
| Clostridium | 0.2721 | 0.0331±0.0062 | 0.0334±0.0055 | 0.0265±0.0083 | 0.0145±0.0025 | 0.0431±0.0075 |
| Collinsella | 0.7476 | 0.0145±0.0035 | 0.0107±0.0038 | 0.0203±0.0126 | 0.0334±0.0174 | 0.0146±0.0045 |
| Dorea | 0.4820 | 0.0218±0.0035 | 0.0126±0.0032 | 0.0174±0.0046 | 0.0152±0.0015 | 0.0137±0.0024 |
| Eubacterium | 0.9619 | 0.0436±0.0070 | 0.0367±0.0064 | 0.0366±0.0085 | 0.0332±0.0058 | 0.0441±0.0063 |
| Faecalibacterium | 0.0077 | 0.0209+0.0037 | 0.0428+0.0093 | 0.0359±0.0139 | 0.0597+0.0098 | 0.0550±0.0086 |
| F. prausnitzii | 0.0054 | 0.0220±0.0041 | 0.0417±0.0092 | 0.0356±0.0137 | 0.0589±0.0095 | 0.0542±0.0085 |
| Prevotella | 0.1687 | 0.0149±0.0118 | 0.0000±0.0000 | 0.0050±0.0046 | 0.0023±0.0020 | 0.0110±0.0086 |
| Roseburium | 0.0327 | 0.0146±0.0037 | 0.0245±0.0075 | 0.0268±0.0138 | 0.0274±0.0081 | 0.0329±0.0056 |
| Ruminococcus | 0.8033 | 0.0384±0.0076 | 0.0293±0.0073 | 0.0620±0.0250 | 0.0394±0.0139 | 0.0376±0.0079 |
| Genus (±species) |
P value vs exposed control | P value vs asymptomatic | |||||
| Mild | Moderate | Severe | Asymptomatic | Mild | Moderate | Severe | |
| B. P value for various levels of severity of symptomatic infection, compared to negative exposed controls and positive asymptomatic subjects, using Dunn’s post-hoc. | |||||||
| Alistipes | >0.9999 | >0.9999 | >0.9999 | >0.9999 | >0.9999 | >0.9999 | >0.9999 |
| Bacteroides | >0.9999 | 0.0078 | >0.9999 | >0.9999 | >0.9999 | >0.9999 | >0.9999 |
| Bifidobacterium | >0.9999 | 0.0006 | 0.0026 | >0.9999 | >0.9999 | 0.0006 | <0.0001 |
| Blautia | 0.4116 | >0.9999 | 0.6373 | >0.9999 | >0.9999 | >0.9999 | >0.9999 |
| Clostridium | >0.9999 | >0.9999 | >0.9999 | 0.4944 | >0.9999 | 0.9841 | >0.9999 |
| Collinsella | >0.9999 | >0.9999 | >0.9999 | >0.9999 | >0.9999 | >0.9999 | >0.9999 |
| Dorea | >0.9999 | >0.9999 | >0.9999 | >0.9999 | >0.9999 | >0.9999 | >0.9999 |
| Eubacterium | >0.9999 | >0.9999 | >0.9999 | >0.9999 | >0.9999 | >0.9999 | >0.9999 |
| Faecalibacterium | >0.9999 | >0.9999 | 0.0082 | >0.9999 | >0.9999 | >0.9999 | 0.1422 |
| F. prausnitzii | >0.9999 | >0.9999 | 0.0109 | >0.9999 | >0.9999 | >0.9999 | 0.1568 |
| Prevotella | >0.9999 | >0.9999 | >0.9999 | >0.9999 | >0.9999 | 0.8916 | >0.9999 |
| Roseburium | >0.9999 | >0.9999 | 0.0196 | >0.9999 | >0.9999 | >0.9999 | >0.9999 |
| Ruminococcus | >0.9999 | >0.9999 | >0.9999 | >0.9999 | >0.9999 | >0.9999 | >0.9999 |
For A and B, bold values indicate p<0.05. Note, no apparently significant (p<0.05) p values were observed in post-hocs, with main effects non-significant.