ChE inhibition effects of Delphinium alkaloids.
Plants | Compounds | Type | EC50 (μM) | |
---|---|---|---|---|
AChE | BChE | |||
D. denudatum | 1β-hydroxy, 14β-acetyl condelphine (317) | B-2 | 19.8 | 31.5 |
Jadwarine-A (270) | B-2 | 9.2 | 19.6 | |
Jadwarine-B (262) | B-2 | 16.8 | 34.7 | |
Isotalatizidine hydrate | B-2 | 12.1 | 21.4 | |
Dihydropentagynine (203) | B-1 | 11.2 | 22.2 | |
Allanzanthane A | — | 8.2 | 18 | |
Galanthamine | — | 10.1 | 20.6 | |
D. brunonianum | Delamide A (420) | Amide | 9.7 | >50 |
Rivastigmine | — | 4.7 | >10 |