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. 2022 May;63(5):672–678. doi: 10.2967/jnumed.121.262530

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Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

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FIGURE 2. — FMI with cetuximab-800CW enables discrimination between positive and negative LNs. (A and B) Representative images of bisected (A) and nonbisected (B) pathologically positive and negative formalin-fixed LNs from subject who was diagnosed with metastases on final histopathology. Increased fluorescence intensity was observed in both bisected and nonbisected pathologically positive LNs, compared with pathologically negative LNs. (C) FI_max is significantly increased in pathologically positive LNs, compared with negative LNs and non-LNs, both in bisected and in nonbisected LNs. (D) Receiver-operating-characteristic curve–based FI_max shows high area under curve of 0.98. ****P < 0.0001.